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The Comments on Professor Christfried Jakob's Contributions made in The Cytoarchitectonics of the Adult Human Cortex, translated by H. Lee Seldon.
Constantin, Baron von Economo,Georg N. Koskinas
Electroneurobiología , 2005,
Abstract: The neuroscientific treatise of 1925 by Constantin von Economo (1876-1931) and Georg Koskinas (1885-1975), an Atlas of the brain cortex, in re-mapping the cytoarchitecture of human brain confirms and develops the 1911 publications by Christfried Jakob (1866-1956), "Vom Tierhirn zum Menschenhirn" and "Das Menschenhirn". The present article gathers all the assessments and technical mentions that Economo and Koskinas made of Jakob's previous contributions. DEUTSCH: 1925 erschienene wissenschaftliche Arbeit des sterreichischen Neurologen Constantin Freiherr von Economo (1876-1931) und Geog Koskinas (1885-1975), in der sie, aufbauend auf den 1911 erschienenen Publikationen Christfried Jakobs (1866-1956) "Vom Tierhirn zum Menschenhirn, vergleichend morphologische, histologische und biologische Studien zur Entwicklung der Grosshirnhemisph ren und ihrer Rinde" und "Das Menschenhirn, Eine Studie über den Aufbau und die Bedeutung seiner grauen Kerne und Rinde". einen Atlas der Cytoarchitektonik der Hirnrinde entwickelt. (Article in English)
Kommentar über die Forschungsergebnissen von Prof. Christfried Jakob in 'Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen' (Deutscher Text).
Constantin, Baron von Economo,Georg N. Koskinas
Electroneurobiología , 2005,
Abstract: 1925 erschienene wissenschaftliche Arbeit des sterreichischen Neurologen Constantin Freiherr von Economo (1876-1931) und Geog Koskinas (1885-1975), in der sie, aufbauend auf den 1911 erschienenen Publikationen Christfried Jakobs (1866-1956) "Vom Tierhirn zum Menschenhirn" und "Das Menschenhirn" einen Atlas der Cytoarchitektonik der Hirnrinde entwickelt. ENGLISH: The neuroscientific treatise of 1925 by Constantin von Economo (1876-1931) and Georg Koskinas (1885-1975), an Atlas of the brain cortex, in re-mapping the cytoarchitecture of human brain confirms and develops the 1911 publications by Christfried Jakob (1866-1956), "Vom Tierhirn zum Menschenhirn, vergleichend morphologische, histologische und biologische Studien zur Entwicklung der Grosshirnhemisph ren und ihrer Rinde" and "Das Menschenhirn , Eine Studie über den Aufbau und die Bedeutung seiner grauen Kerne und Rinde". The present article gathers all the assessments and technical mentions that Economo and Koskinas made of Jakob's previous contributions. (Article in German).
Monte Carlo simulation of activity measurements by means of 4pb-g coincidence system
Takeda, Mauro N.;Dias, Mauro S.;Koskinas, Marina F.;
Brazilian Journal of Physics , 2004, DOI: 10.1590/S0103-97332004000500038
Abstract: the methodology for simulating all detection processes in a 4pb-g coincidence system by means of the monte carlo technique is described. the goal is to predict the behavior of the observed activity as a function of the 4pb detector efficiency. in this approach, the information contained in the decay scheme is used for determining the contribution of all radiations emitted by the selected radionuclide, to the measured spectra by each detector. this simulation yields the shape of the coincidence spectrum, allowing the choice of suitable gamma-ray windows for which the activity can be obtained with maximum accuracy. the simulation can predict a detailed description of the extrapolation curve, mainly in the region where the 4pb detector efficiency approaches 100%, which is experimentally unreachable due to self absorption of low energy electrons in the radioactive source substrate. the theoretical work is being developed with mcnp monte carlo code, applied to a gas-flow proportional counter of 4p geometry, coupled to a pair of nai(tl) crystals. the calculated efficiencies are compared to experimental results. the extrapolation curve can be obtained by means of another monte carlo algorithm, being developed in the present work, to take into account fundamental characteristics of a complex decay scheme, including different types of radiation and transitions. the present paper shows preliminary calculated values obtained by the simulation and compared to predicted analytical values for a simple decay scheme.
Hellenic Association for the Study of the Liver Clinical Practice Guidelines: Autoimmune hepatitis
George N. Dalekos,George V. Papatheodoridis,John Koskinas
- , 2019, DOI: 10.20524/aog.2018.0330
Abstract: Autoimmune hepatitis (AIH) is a relatively rare acute or chronic liver disease of unknown etiology characterized by large heterogeneity. Its distribution is global, covering all ages, both sexes and all ethnic groups. The aim of the present Clinical Practice Guidelines (CPG) of the Hellenic Association for the Study of the Liver was to provide updated guidance and help to gastroenterologists, hepatologists, internists and general practitioners for AIH diagnosis and management. AIH diagnosis is based on clinicopathological characteristics: namely, polyclonal hypergammaglobulinemia, particularly of immunoglobulin G (IgG), circulating autoantibodies, interface hepatitis on liver histology, absence of viral hepatitis, and a favorable response to immunosuppression. Clinical manifestations at disease onset are variable, ranging from asymptomatic to the acute/severe form. Aminotransferase and bilirubin levels vary, while the presence of hepatitis at the histological level is a prerequisite for diagnosis. Autoantibodies are the hallmark for AIH diagnosis; therefore, the CPG describe the appropriate serological algorithm for their detection. AIH therapy should aim to achieve complete biochemical (normalization of IgG and aminotransferases) and histological remission. All patients who have active disease, even those with cirrhosis, should be treated with individualized and response-guided induction therapy using prednisolone in combination with azathioprine or mycophenolate mofetil as first-line therapy. Immunosuppression should be given for at least 3 years and for at least 2 years after the achievement of complete biochemical response, while a liver biopsy should be recommended before treatment discontinuation. Current CPG are also provided for several specific conditions and difficult-to-treat patients
Imagination and concept intertwined
Valeriya N-Georg
- , 2018, DOI: 10.21037/cdt.2017.09.02
Abstract: Valeriya N-Georg is an artist inspired by neuroscience, psychology and consciousness studies, who works with a range of media: drawing, printmaking, sculpture, digital and mixed media. She is interested in exploring the boundaries between the inner and outer body; between the physical and metaphysical; tangible and intangible. N-Georg combines digital production with making by hand and has developed experimental new techniques for making monotype prints, based on layered acrylic gel on boards and light box installations (Figure 1), which she scans, collages and manipulates digitally to create large scale digital prints. Her work is deeply influenced by sources such as Antonio Damasio’s research on the relationship between the brain and the consciousness, the role of emotions and feelings for our life-regulating processes and mental representations of our body states, or Dr. Bruce Lipton’s ideas about interactions between mind and body and the processes by which cells receive information
Imagination and concept intertwined
Valeriya N-Georg
- , 2018,
Abstract: Valeriya N-Georg is an artist inspired by neuroscience, psychology and consciousness studies, who works with a range of media: drawing, printmaking, sculpture, digital and mixed media. She is interested in exploring the boundaries between the inner and outer body; between the physical and metaphysical; tangible and intangible. N-Georg combines digital production with making by hand and has developed experimental new techniques for making monotype prints, based on layered acrylic gel on boards and light box installations (Figure 1), which she scans, collages and manipulates digitally to create large scale digital prints. Her work is deeply influenced by sources such as Antonio Damasio’s research on the relationship between the brain and the consciousness, the role of emotions and feelings for our life-regulating processes and mental representations of our body states, or Dr. Bruce Lipton’s ideas about interactions between mind and body and the processes by which cells receive information
Impact of direct-acting antiviral agents on the development of hepatocellular carcinoma: evidence and pathophysiological issues
John Koskinas,Maria Tampaki,Spiros Savvanis
- , 2018, DOI: 10.20524/aog.2018.0306
Abstract: Hepatitis C virus (HCV) infection is currently one of the main causes of cirrhosis and hepatocellular carcinoma (HCC) at a global level. Recently, a new generation of direct-acting antiviral agents (DAAs) has entered the HCV treatment landscape, providing impressively high rates of sustained virological response (SVR), and is expected to lead to an eventual decrease in HCV-related cirrhosis, liver transplantation and mortality. However, during the first years of their use, several studies reported a possible correlation between DAA treatment and an increased risk of HCC. Following the publication of larger prospective studies, the risk of de novo HCC occurrence has clearly been proven to be lower after the achievement of SVR, regardless of antiviral treatment. On the other hand, the risk of HCC recurrence following treatment with DAAs is debatable; existing data remain controversial, possibly because of the lack of large, well designed cohorts with more homogeneous patient populations. With regard to the pathophysiology behind the above observations, especially in patients with previous HCC history, HCC development could possibly be favored by the changes in the immunological milieu and the different cellular behavior after eradication of HCV infection with DAA treatment
Triple antithrombotic therapy in patients undergoing percutaneous coronary intervention: balancing between ischemia and bleeding
Konstantinos C. Koskinas,Lorenz R？ber
- , 2017, DOI: 10.21037/cdt.2017.04.02
Abstract: We appreciate the commentary by Dr. Shah and colleagues (1) on our paper assessing the duration of triple antithrombotic therapy among patients undergoing percutaneous coronary interventions (PCI) (2). As pointed by the authors, antithrombotic management of patients who undergo PCI with stent implantation and have concomitant indication for long-term oral anticoagulation (OAC) is a common clinical dilemma. While a so-called triple therapy with a combination of dual antiplatelet therapy (DAPT) plus warfarin has been the standard of care in these patients, it results in a higher risk of bleeding compared with less intensive antithrombotic regimens (3). Between the Scylla of ischemic and atherothrombotic risk and the Charybdis of hemorrhage, the question regarding the optimal treatment in this challenging group of patients remains largely unanswered
Triple antithrombotic therapy in patients undergoing percutaneous coronary intervention: balancing between ischemia and bleeding
Konstantinos C. Koskinas,Lorenz R？ber
- , 2017,
Abstract: We appreciate the commentary by Dr. Shah and colleagues (1) on our paper assessing the duration of triple antithrombotic therapy among patients undergoing percutaneous coronary interventions (PCI) (2). As pointed by the authors, antithrombotic management of patients who undergo PCI with stent implantation and have concomitant indication for long-term oral anticoagulation (OAC) is a common clinical dilemma. While a so-called triple therapy with a combination of dual antiplatelet therapy (DAPT) plus warfarin has been the standard of care in these patients, it results in a higher risk of bleeding compared with less intensive antithrombotic regimens (3). Between the Scylla of ischemic and atherothrombotic risk and the Charybdis of hemorrhage, the question regarding the optimal treatment in this challenging group of patients remains largely unanswered
ISO/IEC 27000, 27001 and 27002 for Information Security Management  [PDF]
Georg Disterer
Journal of Information Security (JIS) , 2013, DOI: 10.4236/jis.2013.42011
Abstract:

With the increasing significance of information technology, there is an urgent need for adequate measures of information security. Systematic information security management is one of most important initiatives for IT management. At least since reports about privacy and security breaches, fraudulent accounting practices, and attacks on IT systems appeared in public, organizations have recognized their responsibilities to safeguard physical and information assets. Security standards can be used as guideline or framework to develop and maintain an adequate information security management system (ISMS). The standards ISO/IEC 27000, 27001 and 27002 are international standards that are receiving growing recognition and adoption. They are referred to as “common language of organizations around the world” for information security [1]. With ISO/IEC 27001 companies can have their ISMS certified by a third-party organization and thus show their customers evidence of their security measures.

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